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MaterniT21 test accuracy. BunnyGirl19 Due December 13; 3 kids; 10 angel babies; Oregon 16714 posts
status 21st Mar '13

So, I have a weird problem. I know, so what else is new? LOL! Anyways, I had MaterniT21 test done along with my standard first trimester screen at a little past 10 weeks. I got the results on Monday and they said that with 97% accuracy I'm having a boy, possible error due to being on injectable anticoagulants (Lovenox) and recent past boy pregnancies. Well, they also drew a second MaterniT21 test at 15 weeks along with my standard second trimester screening (my doctor ordered it twice). I got called today and told that I'm having a girl, with 99% accuracy. What the heck?!!! I'm questioning this whole test now and if they can be accurate with the other results (negative screenings) when they came up with different genders 5 weeks apart. And I'm wondering which one is more likely to be accurate, the one at 10 weeks or the one at 15 weeks? Does anyone else have experience with this test and was it reliable for you?

Amelia [a Mom] 1 child; 4 angel babies; Tallahassee, Florida 14998 posts
21st Mar '13

Sorry I'm no help just have a question. Do you pay out of pocket for it? If not, do you have elevated risks requiring this test over other genetic screening? It has never been offered to me, despite seeing and MFM and I would like to get the test next time. Despite the questionable gender accuracy. :o Makes me wonder too, if this is inaccurate could other parts of the test be inaccurate as well.

Red Bottom 2 kids; Middelfart, Denmark 15275 posts
21st Mar '13

Unless this is a blood of fluid test, it's 50/50.

Amelia [a Mom] 1 child; 4 angel babies; Tallahassee, Florida 14998 posts
21st Mar '13
Quoting Red Bottom:" Unless this is a blood of fluid test, it's 50/50."


It's a DNA test.

NICKEL☮POLIS 2 kids; Ontario 6263 posts
21st Mar '13
Quoting BunnyGirl19:" So, I have a weird problem. I know, so what else is new? LOL! Anyways, I had MaterniT21 test done along ... [snip!] ... the one at 10 weeks or the one at 15 weeks? Does anyone else have experience with this test and was it reliable for you?"


I'd go with the higher percentage. Maybe have a 3D ultrasound done? So you can see the private bits in detail :)

Red Bottom 2 kids; Middelfart, Denmark 15275 posts
21st Mar '13

<blockquote><b>Quoting Amelia Margaret:</b>" It's a DNA test."</blockquote>




Oh. Well sex organs don't develop until 15 weeks, as far as differentiating, though DNA sex DNA is established at fertilization.

BunnyGirl19 Due December 13; 3 kids; 10 angel babies; Oregon 16714 posts
status 21st Mar '13

<blockquote><b>Quoting Amelia Margaret:</b>" Sorry I'm no help just have a question. Do you pay out of pocket for it? If not, do you have elevated ... [snip!] ... gender accuracy. :o Makes me wonder too, if this is inaccurate could other parts of the test be inaccurate as well."</blockquote>




I see perinatology and it was covered by my insurance. I've read it costs $1900 without insurance. I'm high risk with a blood clotting disorder.

BunnyGirl19 Due December 13; 3 kids; 10 angel babies; Oregon 16714 posts
status 21st Mar '13

<blockquote><b>Quoting Red Bottom:</b>" Unless this is a blood of fluid test, it's 50/50."</blockquote>




It tests the plasma in your blood for fetal chromosomes.

Karen L.S. TTC since Aug 2013; 5 kids; Texas 283 posts
21st Mar '13

I had this test done at 17 weeks along with an ultrasound. They said it was a boy during the ultrasound. When the test came back they said it was a boy due to the y chromosome found. I just had another ultrasound this week by the maternal fetal specialist and again confirmed it was a boy. Apparently he likes to show off his boy parts. --- I know the test isn't recommended till at least 10 weeks. It also has an 98% accuracy testing for downs. It seems they already suspected your test might have problems due to issues. Unfortunately nothing is 100% and someone had to be the 2% that the test fails. You really need to talk to your specialist about the results and see what they think. --- Good luck

BunnyGirl19 Due December 13; 3 kids; 10 angel babies; Oregon 16714 posts
status 21st Mar '13

<blockquote><b>Quoting Karen L.S.:</b>" I had this test done at 17 weeks along with an ultrasound. They said it was a boy during the ultrasound. ... [snip!] ... the 2% that the test fails. You really need to talk to your specialist about the results and see what they think. --- Good luck"</blockquote>




I actually had it done twice because I'm part of a study (there is a study being done to determine if injectable anticoagulants can affect the results due to it being made from the mucus of pig intestines, which potentially introduces outside DNA into the bloodstream). The other results came back in line with the results of my standard screen for the chromosomal defects, but gender has been inconsistent. I don't know if other study participants have this issue as well or not.

Karen L.S. TTC since Aug 2013; 5 kids; Texas 283 posts
21st Mar '13

Wow didn't even know there was a study but I don't take blood thinner . My mom does but since she is past the childbearing stage and had a hysterectomy I don't think she would be asked to participate in the study. lol ---- Now that has me wondering how long they think the pig DNA would stay in the system if someone quit taking the blood thinners.

BunnyGirl19 Due December 13; 3 kids; 10 angel babies; Oregon 16714 posts
status 21st Mar '13

<blockquote><b>Quoting Karen L.S.:</b>" Wow didn't even know there was a study but I don't take blood thinner . My mom does but since she is ... [snip!] ... Now that has me wondering how long they think the pig DNA would stay in the system if someone quit taking the blood thinners."</blockquote>




I thought it would be a good study to be in. I'm wondering if it skews the gender accuracy of it because there is that similar Pink or Blue test you can do where it tests your blood looking for Y chromosomes. There test specifically states it shouldn't be used by patients on anticoagulants (doesn't specify injectable or not) because it would affect accuracy. When I called customer service they said it can detect Y chromosomes that aren't really there. This has me super curious now, but I'm sure we won't see the study for a few more years considering the test in general is only a couple years old and not even FDA approved yet last I heard.

***Team Jacob*** 2 kids; California 4066 posts
22nd Mar '13

the materni21 is like the most accurate test out there right now thats nuts that they gave u different results!! i guess soon enough youll know. but that stinks!!

Karen L.S. TTC since Aug 2013; 5 kids; Texas 283 posts
22nd Mar '13
Quoting BunnyGirl19:" <blockquote><b>Quoting Karen L.S.:</b>" Wow didn't even know there was a study but ... [snip!] ... for a few more years considering the test in general is only a couple years old and not even FDA approved yet last I heard."

I found out that are doing a study right now and hope to have the results by September. I read that the the lab that does them are FDA approved but the test isn't so far. The test isn't required to be FDA approved.They are seek the approval so they can make a kit for other labs. Over seas they have been doing this kind of testing for sometime. In Europe I believe. Sometimes it takes things longer to be approved in the US. Everything I have read it still has a very good accuracy to detect downs. ---- I am assuming the premise of the test is if they find the downs gene in a woman who doesn't have downs it can only be the baby's . So far it's the most accurate non invasive way to detect downs. One of the fears people have had was if more women knew for certain their babies would have downs or knew the gender of the baby there would be more abortions. --- Personally I was keeping this baby no matter what issues he might have had. Since I wouldn't have a amnio this is the best test for me. -- I guess in 14 weeks or less I will know for certain if the test was accurate.

BunnyGirl19 Due December 13; 3 kids; 10 angel babies; Oregon 16714 posts
status 22nd Mar '13

<blockquote><b>Quoting Karen L.S.:</b>" I found out that are doing a study right now and hope to have the results by September. I read that the ... [snip!] ... have a amnio this is the best test for me. -- I guess in 14 weeks or less I will know for certain if the test was accurate."</blockquote>




Yeah, I want the testing so I could be prepared if there is a problem pretty much, not to terminate. I've had amnios before and this time I didn't get one so far because I was doing a study for this test. I'm wondering if me being on Lovenox just screws with the gender accuracy versus the other parts of the test since the results were basically the same for those between the two? I should be finding out gender sometime next month if baby is cooperative finally (last scan legs were crossed and the cord was running between them so we couldn't see).