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Hodgkin Lymphoma During Pregnancy May Cause Complications But Does Not Affect Maternal Survival

A new research study conducted shows that women who are diagnosed with the specific cancer known as Hodgkin lymphoma (HL) during pregnancy does not seem to reduce the 5-year period of overall survival for these mothers.

According to Oncology Nurse Advisor, the study did find that a diagnosis can, unfortunately, result in pregnancy and delivery complications, such as preterm devilry and low birthweight. This is according to the most recent findings of the study, which were presented at ESMO Congress of 2019 held in Barcelona, Spain.

In order to complete the study, researchers used data from the International Network on Cancer registry. The workers used this information to cross-check and then, identified, assessed and double-cross-checked medical and confidential patient data from 134 pregnant patients, who happened to be diagnosed with Hodgkin lymphoma between 1969 to 2018. It is important to note that the study included a small number of women with advanced stages of HL.

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Researchers ultimately discovered that the survival of pregnant patients with what is referred to as "classical HL" was compared with that on nonpregnant patients with classical HL. This basically means the pregnancy had no part in the effects of the disease advancing, or in this case, not advancing.

Both groups of patients studied were found to have the same state of prognostic scores at the time of their diagnosis and each patient was treated with an appropriate ABVD program. ABVD stands for adriamycin, bleomycin sulfate, vinblastine sulfate, and dacarbazine which are the chemicals used in chemotherapy.

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In the study, researchers pinpointed the estimated gestational age at the time of the mother's diagnosis was around 20 weeks of pregnancy. 47 of these patients experienced preterm delivery. 53.7% of the patients involved in the study overall chose to get involved with an ABVD-based treatment program while pregnant despite the health risks to the unborn babies. Overall, a total of 120 patients or 89.6 pregnancies resulted in live births. Of these, 47 women experienced preterm delivery. 3.5% of the babies were born with major congenital malformations.

In the end, it is comforting to know that according to the study, being diagnosed with the disease during pregnancy isn't the end of the world. Chances of maternal survival are extremely high! The 5-year progression-free survival for expectant mothers who are diagnosed with early- and late-stage Hodgkin lymphoma was 82.5% and 90.9% respectively while the 5-year overall survival was 97.3% and 100% for mothers with early and advanced HL.

What do you think about the results of this study? We would love to know your thoughts down in the comments!

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